The purpose of the present study was to develop an optimized matrix tablet of bupropion hydrobromide. The model drug is highly soluble in water and the matrix tablet of the same has shown drug release for 12 hours. The FTIR analysis shows that there is no significant interaction between drug and polymers used in the formulation. An augmented simplex centroid design was constructed for optimizing matrix tablets of bupropion hydrobromide, where the amounts of xanthan gum (X1), guar gum (X2) and sodium alginate (X3) were selected as the independent variables. Drug release at 12th h (Y1) and time required for 50% drug release (Y2) were selected as dependent variables. All other variables due to formulations and processing were kept invariant throughout the study. Results of evaluation of matrix tablet shows that, optimized formulation containing 3.33% of xanthan gum, 4.44 % of guar gum and 4.44 % of sodium alginate show 98.63±1.72 % drug release at 12th h and 50% drug release in 2.69±0.58 h. Swelling of the tablets increased with an increased amount of sodium alginate up to 8 h further the tablet starts to erode. All the gums contribute for the swelling behavior of the tablet and also help to maintain the integrity of tablet throughout the study.
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